Developing new asymmetric catalytic reactions for the synthesis of complex molecules
Do Hyun Ryu's research team in the Department of Chemistry at Sungkyunkwan University (SKKU) has developed two new asymmetric catalytic methods for the precise synthesis of complex molecules using chiral organic catalysts.
Do Hyun Ryu's research team in the Department of Chemistry at Sungkyunkwan University (SKKU) has developed two new asymmetric catalytic methods for the precise synthesis of complex molecules using chiral organic catalysts.
The short version
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- The team demonstrated that a single catalyst can promote two different carbon-carbon bond-forming reactions with high selectivity.
- They also developed a method to selectively construct complex ring structures with multiple stereocenters from simple starting materials.
What happened
Both studies were published in Angewandte Chemie International Edition . The selective synthesis of molecules with the desired structure is important for producing complex molecules such as pharmaceuticals and natural products.
Why it matters
In particular, precisely controlling where a reaction occurs and how atoms are arranged in three-dimensional space is essential because these structural features can determine a molecule's properties and functions.
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