Shear flow in narrow channels sparks amyloid formation, experiments reveal
Many cars and not enough lanes is a recipe for traffic jams.
Many cars and not enough lanes is a recipe for traffic jams.
The short version
- Now, researchers from Japan show that even proteins can get backed up and start behaving poorly when too many try to squeeze too quickly through a small space.
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What happened
In a study published in The FEBS Journal , researchers from the University of Osaka report real-time observation of the formation of amyloid triggered by shear stress. Amyloid fibrils occur in diseases like Alzheimer's and Parkinson's.
Why it matters
In amyloidogenic light chain disease, these fibrils accumulate in the heart, where they are subjected to shear stress due to blood flow and changing blood vessel sizes caused by the heart beating.
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